Where's the middle of nowhere?

It's three letters in. "H".

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Middle Jokes More Middle Jokes

Whats the best place to drive to in Iowa?

The Middle. That way, you're always driving out of Iowa.

What would be your reply?

Someone stops you in the middle of the road and asks you to tell him a good joke, What would be your reply?

Letter Jokes More Letter Jokes

What starts with e, ends with e, and only contains one letter?

an Envelope EDIT: My deepest Canadian apologies to those who are calling this a riddle. I always took it as a cheesy joke

What do you call a Welshman who writes lots of letters ?

Pen Gwyn !

H Jokes More H Jokes

What does a guy who can predict the lottery numbers 99% of the time have in common with the letters C, D, G, H, J, K, M, N, O, P, Q, R, S, T, U, V, W, X, Y, and Z?

They're not infallible

What does the H. in Jesus H. Christ stand for?

Hallmark. God cares enough to send the very best.